DNA usually forms the classic double helix shape — two strands wound around each other. But approximately 1% of the human genome has the ability to fold into four-stranded ‘quadruple helix’ DNA structures called G-quadruplexes (G4s). G4s regulate several key cellular processes (e.g., transcription) and have been hypothesized to participate in others. In new research, a team of scientists at Penn State University conducted the first genome-wide...
